Malate—CoA ligase
| malate-CoA ligase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 6.2.1.9 | ||||||
| CAS number | 37318-58-4 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a malate-CoA ligase (EC 6.2.1.9) is an enzyme that catalyzes the chemical reaction
- ATP + malate + CoA
ADP + phosphate + malyl-CoA
The 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is malate:CoA ligase (ADP-forming). Other names in common use include malyl-CoA synthetase, malyl coenzyme A synthetase, and malate thiokinase. This enzyme participates in glyoxylate and dicarboxylate metabolism.